Table 4.
Dosage Frequency | Best Guess Count | |||||||
---|---|---|---|---|---|---|---|---|
HLA Allele | Cases | Controls | Cases | Controls | OR (95% CIA) | Single Locus P-value | Stepwise P-value | Stepwise OR (95%CIA) |
DQB1*0602B | 0.25 | 0.15 | 301 | 636 | 1.90 (1.62 - 2.21) | 5.55×10−16 | 1.93×10−23 | 2.35 (1.99 – 2.78) |
DRB1*0803 | 0.20 | 0.13 | 251 | 613 | 1.59 (1.34 - 1.88) | 7.37×10−8 | 7.63×10−16 | 2.14 (1.78 - 2.58) |
DQB1*0202 | 0.18 | 0.12 | 212 | 502 | 1.60 (1.35 - 1.90) | 7.57×10−8 | 2.19×10−18 | 2.50 (2.04 - 3.07) |
DQA1*0302 | 0.19 | 0.16 | 286 | 847 | 1.41 (1.15 - 1.75) | 1.27×10−3 | 4.92×10−9 | 1.98 (1.58 - 2.50) |
B*0801 | 0.02 | 0.004 | 20 | 14 | 5.43 (2.66 - 11.08) | 3.42×10−6 | 5.15×10−6 | 5.71 (2.70 -12.07) |
DQA1*0401 | 0.04 | 0.03 | 54 | 133 | 1.73 (1.17 - 2.57) | 5.94×10−3 | 3.11×10−5 | 2.36 (1.58 - 3.54) |
C*0702 | 0.22 | 0.17 | 261 | 711 | 1.37 (1.17 - 1.59) | 5.45×10−5 | 2.06×10−3 | 1.30 (1.10 - 1.54) |
DRB1*0406 | 0.03 | 0.07 | 41 | 354 | 0.15 (0.09 - 0.26) | 2.63×10−11 | 1.11×10−4 | 0.32 (0.18 - 0.57) |
DPB1*0501 | 0.79 | 0.72 | 930 | 3092 | 1.16 (1.05 - 1.28) | 2.87×10−3 | 1.06×10−4 | 1.23 (1.11 - 1.36) |
DRB1*1602 | 0.03 | 0.02 | 38 | 87 | 1.78 (1.16 - 2.72) | 7.73×10−3 | 1.53×10−3 | 2.05 (1.32 - 3.20) |
DPB1*1701 | 0.03 | 0.04 | 41 | 160 | 0.90 (0.62 - 1.30) | 5.66×10−1 | 1.07×10−3 | 0.5 (0.33 - 0.76) |
C*0102 | 0.29 | 0.32 | 359 | 1429 | 0.88 (0.77 - 1.01) | 6.51×10−2 | 5.82×10−3 | 0.82 (0.71 - 0.94) |
DRB1*1202 | 0.04 | 0.07 | 39 | 266 | 0.52 (0.37 - 0.74) | 2.98×10−4 | 7.07×10−3 | 0.61 (0.42 - 0.87) |
CI = Confidence interval
The allele HLA-DRB1*1501 had the same P-value as HLA-DQB1*0602, but the later was selected by the stepwise modeling procedure. For complete results, please refer to Supplementary Table 5.
Note: Tables are in the order they were identified in the stepwise model. The stepwise results presented in this table are for adjusting for all other variants in the table