Table 1. Development of the cognitive domains.

Cognitive domain	Neuropsychological subtests	Description of test used for cognitive domain scores
Estimated premorbid IQ	Vocabulary subtest of WAIS-IIIa/ WISC-IVb	Give oral definitions for words. Measure: direct score and standardized score.Estimated premorbid IQ is calculated from the standardized score: (SS × 5) + 50.
Processing speed	Trail Making Testc-form A	Connect in proper order, by making pencil lines, 25 encircled numbers randomly arranged on a page.Measure: time to complete this (form A)
	Stroop Test word and colour conditiond	Read the words and the colours of a series of XXXX as quickly as possible in 45 s. Measure: number of items completed.
Attention	CPT-IIe	Respond to a series of letters on a computer screen by pressing a key when you detect letters other than the letter “X”. The assessment contains six blocks that vary in the rate of submission of the letters. Measure: mean response sensitivity (D-prime).
Verbal memory	TAVECf	Recall as many words as possible from a list of 16 words read aloud by the tester. The procedure is repeated five times, and recall is tested immediately and after a delay. Measure: total number of words recalled after the five trials, immediately and delayed.
Working memory	Digit Span subtest of the WAIS-IIIa/ WISC-IVb	Repeat a number sequence in the same and order as presented and in reverse. Measure: total number of series correctly repeated forwards, backwards, and the sum of both.
	Letter and number sequencing of the WAIS-IIIa/ WISC-IVb	Listen to a combination of numbers and letters read aloud by the tester and reorganize the sequence, listing first the numbers in ascending order and then the letters in alphabetical order. Measure: number of correct sequences.
Executive function	FAS testg	Generate as many words as possible beginning with F, A and S, in three separate trials of 60 s. Measure: the sum of all correct responses
	Animal wordsh	Produce as many animal names as possible in a 1-min period. Measure: number of correct responses.
	Trail Making Testc-form B	Draw lines connecting characters, alternating sequentially between numbers and letters. Measure: time to complete this (form B), B/A ratio (time to complete form B divided by time to complete form A).
	WCSTi	Complete a complex task of categorization set shifting, and respond to feedback from the computer.Measure: number of completed categories and percentage of conceptual responses, total errors and perseverative errors.
	Stroop Testd- interference condition	Name the colour in which the colour names are printed, disregarding their verbal content. Measure: Interference Index (WC − WxC /W+ C).
Cognitive Global Index	Processing speed	A Global Cognitive Index score was calculated by averaging scores for all cognitive domains, except the estimated premorbid IQ.
	Attention
	Verbal memory
	Working memory
	Executive function

^aWechsler Adult Intelligence Scale III (WAIS-III) [33].

^bWechsler intelligence Scale for children-IV (WISC-IV) [34].

^cTrail Making Test [35].

^dStroop Test [36].

^eConners’ Continuous Performance Test (CPT-II) [37].

^fTest de Aprendizaje Verbal España-Complutense (TAVEC) [38].

^gControlled Oral Word Association Test (FAS test) [39].

^hAnimal words [40].

ⁱWisconsin Card Sorting Test (WCST) [41].