Table 3. Hierarchical-regression models between subject type, cannabis use and cognition.
| Variables in the modela | β | P-value | 95% CI | R2 | |
|---|---|---|---|---|---|
| Processing speed | Cannabis: users (vs. ref) | 0.002 | 0.990 | -0.297, 0.280 | 0.315 |
| Subject type: FH+ (vs. ref) | -0.392 | 0.012 | -0.680, -0.071 | ||
| Subject type: Controls (vs. ref) | 0.626 | 0.003 | 0.410, 0.885 | ||
| Cannabis*Subject type: users*FH+ patients (vs. ref) | 0.344 | 0.170 | -0.139, 0.844 | ||
| Cannabis*Subject type: users*controls (vs. ref) | -0.174 | 0.417 | -0.590, 0.248 | ||
| Attention | Cannabis: users (vs. ref) | 0.113 | 0.253 | -0.073, 0.308 | 0.055 |
| Subject type: FH+ (vs. ref) | 0.053 | 0.604 | -0.152, 0.247 | ||
| Subject type: Controls (vs. ref) | -0.113 | 0.160 | -0.280, 0.033 | ||
| Cannabis*Subject type: users*FH+ patients (vs. ref) | -0.224 | 0.187 | -0.556, 0.103 | ||
| Cannabis*Subject type: users*controls (vs. ref) | -0.199 | 0.166 | -0.476, 0.082 | ||
| Verbal memory | Cannabis: users (vs. ref) | -0.262 | 0.079 | -0.550, 0.036 | 0.378 |
| Subject type: FH+ (vs. ref) | -0.324 | 0.046 | -0.603, 0.004 | ||
| Subject type: Controls (vs. ref) | 0.748 | <0.001 | 0.530, 1.007 | ||
| Cannabis*Subject type: users*FH+ patients (vs. ref) | 0.720 | 0.004 | 0.219, 1.211 | ||
| Cannabis*Subject type: users*controls (vs. ref) | -0.096 | 0.659 | -0.528, 0.333 | ||
| Working memory | Cannabis: users (vs. ref) | -0.479 | 0.043 | -0.936, -0.019 | 0.116 |
| Subject type: FH+ (vs. ref) | -0.571 | 0.020 | -1.021, -0.066 | ||
| Subject type: Controls (vs. ref) | 0.018 | 0.927 | -0.325, 0.423 | ||
| Cannabis*subject type: users*FH+ patients (vs. ref) | 0.654 | 0.101 | -0.129, 1.427 | ||
| Cannabis*subject type: users*controls (vs. ref) | 0.260 | 0.447 | -0.417, 0.916 | ||
| Executive Function | Cannabis: users (vs. ref) | -0.171 | 0.019 | -0.305, -0.018 | 0.266 |
| Subject type: FH+ (vs. ref) | -0.208 | 0.005 | -0.342, -0.051 | ||
| Subject type: controls (vs. ref) | 0.159 | 0.007 | 0.062, 0.294 | ||
| Cannabis*subject type: users*FH+ patients (vs. ref) | 0.224 | 0.047 | 0.007, 0.476 | ||
| Cannabis*subject type: users*controls (vs. ref) | 0.175 | 0.091 | -0.045, 0.363 | ||
| Cognitive global Index | Cannabis: users (vs. ref) | -0.134 | 0.118 | -0.303, 0.034 | 0.407 |
| Subject type: FH+ (vs. ref) | -0.305 | <0.001 | -0.475, -0.134 | ||
| Subject type: controls (vs. ref) | 0.287 | <0.001 | 0.154, 0.420 | ||
| Cannabis*subject type: users*FH+ patients (vs. ref) | 0.314 | 0.031 | 0.029, 0.598 | ||
| Cannabis*subject type: users*controls (vs. ref) | -0.014 | 0.910 | -0.252, 0.225 |
a Variables in the model: IQ, alcohol at baseline, cannabis use at baseline (yes/no), subject type (FH- patients/ FH+ patients/controls).
References groups: for the use of cannabis at baseline: no use; for the subject type variable: FH- patients.