Skip to main content
. 2016 Aug 11;11(8):e0161040. doi: 10.1371/journal.pone.0161040

Fig 1. Effect of S4 on doxorubicin sensitivity in MDA-MB-231 and FaDu cells.

Fig 1

CAIX protein expression is higher during hypoxia in MDA-MB-231 and FaDu cells (A). Quantification of three independent biological repeats shows an almost twofold increase in CAIX expression (normalized to actin expression levels) in both cell lines (B). Cell viability assays of MDA-MB-231 (C) and FaDu cells (D) with increasing concentrations of doxorubicin. Cells were exposed to vehicle (black) or S4 (green) during normoxia (N), or to vehicle (red) or S4 (blue) during hypoxia (H). Results of three independent biological repeats are shown (mean ± SEM).