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. 2016 Aug 11;11(8):e0160622. doi: 10.1371/journal.pone.0160622

Fig 4. DHA consumption suppresses cSiO2-induced glomerulonephritis in NZBWF1 mice.

Fig 4

Representative photomicrographs of H&E stained kidney section in NZBWF1 (A-C) and NZW/LacJ (D-F). Letters indicate CON-fed, VEH-exposed mice (A, D), CON-fed, cSiO2-exposed mice (B, E) and 2.4% DHA-fed, cSiO2-exposed mice(C, F). CON-fed NZBWF1 mice instilled with cSiO2 (B) developed extensive glomerulonephritis (black arrows) and tubular proteinosis (*). Mild histopathological lesions were also observed in some NZW/LacJ mice exposed to cSiO2 (E). Dietary supplementation with 2.4% DHA decreased severity of lesions in cSiO2-exposed NZBWF1(C), and NZW/LacJ mice (F).