Fig 6. DHA supplementation prevents cSiO₂-induced pneumonitis.

Representative photomicrographs of H&E stained lung sections from NZBWF1 (A-C) and NZW/LacJ (D-F) mice exposed to VEH (A, D), cSiO₂ fed CON diet (B, E), and cSiO₂ fed 2.4% DHA (C, F). Black arrows in light photomicrographs denote marked leukocyte infiltration that circumvented both the vasculature and airways in the lung following cSiO₂ exposure (B). Dietary DHA dramatically reduced cSiO₂-induced pulmonary inflammation as evident by the absence of cellular accumulation in (C, F). Lymphocytic cell infiltration was semi-quantitatively graded as indicated in Table 3). Abbreviations: ba = bronchiolar airway, v = blood vessel, tb = terminal bronchiole, a = alveolus.