Fig 12. cSiO₂ -induced elevation of B cell stimulating cytokines BAFF and osteopontin are decreased in BALF and plasma in NZBWF1 mice fed DHA.

B cell stimulating cytokines B cell activating factor (BAFF) (A, C) and osteopontin (OPN) (B, D) were quantitated by ELISA in BALF (left panel) and plasma (right panel). Data are $\overline{\mathrm{x}}$ ± SEM (n = 8). Symbols: * indicates significant difference from CON-fed mice instilled with VEH (p < 0.05); # indicates significant difference from CON-fed mice instilled with cSiO₂ (p < 0.05). DHA dose-dependently decreased BAFF in BALF (r² = -0.507, p < 0.05) and plasma (r² = -0.539, p < 0.05). DHA dose-dependently decreased OPN in BALF (r² = -0.330, p = 0.06) and in plasma (r² = -0.493, p < 0.05).