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. 2016 Aug 11;11(8):e0160993. doi: 10.1371/journal.pone.0160993

Fig 1. Linagliptin suppresses peritoneal cell density and thickening in methylglyoxal (MGO)-injected mice.

Fig 1

(a, b) Representative light microscopy of peritoneal tissues on day 21 (a: hematoxylin-eosin staining; b: Masson’s trichrome staining; original magnification: ×200) in control mice, MGO-injected mice treated with saline, and MGO-injected mice treated with linagliptin. (c, d) The thickness of the submesothelial compact zone increased along with its cellularity until day 21 in mice treated with saline, whereas cell density and zone thickening were suppressed in mice treated with linagliptin. Bars indicate the compact zone area. Statistical analyses were performed using analysis of variance (ANOVA) followed by Tukey’s post-hoc test. *P < 0.05.