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. 2016 Aug 11;11(8):e0160993. doi: 10.1371/journal.pone.0160993

Fig 4. Linagliptin attenuates monocyte/macrophage infiltration and transforming growth factor-β1 (TGF-β1) expression in mice with peritoneal fibrosis.

Fig 4

(a) Immunohistochemical analysis of F4/80 expression in peritoneal tissue on day 21 in control mice, MGO-injected mice treated with saline, and MGO-injected mice treated with linagliptin. (b) Immunohistochemical analysis of TGF-β1 expression in peritoneal tissues on day 21 in MGO-injected mice treated with saline and MGO-injected mice treated with linagliptin. (c) The number of F4/80-expressing cells increased until day 21 in MGO-injected mice treated with saline, but significantly decreased by day 21 in MGO-injected mice treated with linagliptin. (d) The number of TGF-β1-expressing cells increased until day 21 in MGO-injected mice treated with saline, but significantly decreased by day 21 in MGO-injected mice treated with linagliptin. Statistical analyses were performed using ANOVA followed by Tukey’s post-hoc test. *P < 0.05 (original magnification in a and b: ×400).