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. 2016 Aug 11;11(8):e0160993. doi: 10.1371/journal.pone.0160993

Fig 6. GLP-1R is expressed in infiltrated inflammatory cells and MGO-induced GLP-1 expression is suppressed by linagliptin.

Fig 6

(a) Expression of GLP-1R was examined by western blotting. GLP-1R was expressed in the monocyte/macrophage cell line THP-1, but not in HPMCs. (b) Immunohistochemical analysis of GLP-1R expression in peritoneal tissue on day 21 in control mice, MGO-injected mice treated with saline, and MGO-injected mice treated with linagliptin. (c) The number of GLP-1R-expressing cells was increased until day 21 in MGO-injected mice treated with saline, but it was significantly decreased by day 21 in MGO-injected mice treated with linagliptin. Statistical analyses were performed using ANOVA followed by Tukey’s post-hoc test. *P < 0.05. (original magnification in b: ×200).