Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1983 Feb;36(2):161–166. doi: 10.1136/jcp.36.2.161

A possible route for lymphocyte migration into diseased tissues

AJ Freemont 1
PMCID: PMC498143  PMID: 6826771

Abstract

Vessels within the lymphocytic infiltrate in 161 examples of 24 different diseases have been studied using light and electron microscopy and histochemistry. Hitherto undescribed venules have been identified within lymphocyte aggregates which exhibit a structure, ultrastructure and cytochemistry previously believed to be restricted to the high endothelial venules of lymphoid tissues. The significance of these findings is discussed within the context of lymphocyte migration into abnormal tissue.

Full text

PDF
161

Images in this article

162Image
on p.162
163Image
on p.163
163Image
on p.163
164Image
on p.164
164Image
on p.164

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson A. O., Anderson N. D. Studies on the structure and permeability of the microvasculature in normal rat lymph nodes. Am J Pathol. 1975 Sep;80(3):387–418. [PMC free article] [PubMed] [Google Scholar]
  2. Anderson N. D., Anderson A. O., Wyllie R. G. Specialized structure and metabolic activities of high endothelial venules in rat lymphatic tissues. Immunology. 1976 Sep;31(3):455–473. [PMC free article] [PubMed] [Google Scholar]
  3. Andrews P., Ford W. L., Stoddart R. W. Metabolic studies of high-walled endothelium of postcapillary venules in rat lymph nodes. Ciba Found Symp. 1980;71:211–230. doi: 10.1002/9780470720547.ch12. [DOI] [PubMed] [Google Scholar]
  4. BALL J., JACKSON D. S. Histological, chromatographic and spectrophotometric studies of toluidine blue. Stain Technol. 1953 Jan;28(1):33–40. doi: 10.3109/10520295309112633. [DOI] [PubMed] [Google Scholar]
  5. Bloom H. J., Richardson W. W., Field J. R. Host resistance and survival in carcinoma of breast: a study of 104 cases of medullary carcinoma in a series of 1,411 cases of breast cancer followed for 20 years. Br Med J. 1970 Jul 25;3(5716):181–188. doi: 10.1136/bmj.3.5716.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Claesson M. H., Jorgensen O., Ropke C. Light and electron microscopic studies of the paracortical post-capillary high-endothelial venules. Z Zellforsch Mikrosk Anat. 1971;119(2):195–207. doi: 10.1007/BF00324521. [DOI] [PubMed] [Google Scholar]
  7. Edwards A. J., Rowland G. F., Lee M. R. Reduction of lymphocyte transformation by a factor produced by gastrointestinal cancer. Lancet. 1973 Mar 31;1(7805):687–689. doi: 10.1016/s0140-6736(73)91477-3. [DOI] [PubMed] [Google Scholar]
  8. Freemont A. J., Davies J. S. Acid esterase activity in lymphocytes and other cells: a comparison of six alpha-naphthyl based substrates. Med Lab Sci. 1982 Oct;39(4):405–407. [PubMed] [Google Scholar]
  9. GOWANS J. L., KNIGHT E. J. THE ROUTE OF RE-CIRCULATION OF LYMPHOCYTES IN THE RAT. Proc R Soc Lond B Biol Sci. 1964 Jan 14;159:257–282. doi: 10.1098/rspb.1964.0001. [DOI] [PubMed] [Google Scholar]
  10. Graham R. C., Jr, Shannon S. L. Peroxidase arthritis. II. Lymphoid cell-endothelial interactions during a developing immunologic inflammatory response. Am J Pathol. 1972 Oct;69(1):7–24. [PMC free article] [PubMed] [Google Scholar]
  11. HOLT S. J., HOBBIGER E. E., PAWAN G. L. Preservation of integrity of rat tissues for cytochemical staining purposes. J Biophys Biochem Cytol. 1960 Apr;7:383–386. doi: 10.1083/jcb.7.2.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Röpke C., Jorgensen O., Claësson M. H. Histochemical studies of high-endothelial venules of lymph nodes and Peyer's patches in the mouse. Z Zellforsch Mikrosk Anat. 1972;131(3):287–297. doi: 10.1007/BF00582852. [DOI] [PubMed] [Google Scholar]
  13. SMITH C., HENON B. K. Histological and histochemical study of high endothelium of post-capillary veins of the lymph node. Anat Rec. 1959 Nov;135:207–213. doi: 10.1002/ar.1091350306. [DOI] [PubMed] [Google Scholar]
  14. Schoefl G. I. The migration of lymphocytes across the vascular endothelium in lymphoid tissue. A reexamination. J Exp Med. 1972 Sep 1;136(3):568–588. doi: 10.1084/jem.136.3.568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Smith J. B., McIntosh G. H., Morris B. The traffic of cells through tissues: a study of peripheral lymph in sheep. J Anat. 1970 Jul;107(Pt 1):87–100. [PMC free article] [PubMed] [Google Scholar]
  16. Underwood J. C. Lymphoreticular infiltration in human tumours: prognostic and biological implications: a review. Br J Cancer. 1974 Dec;30(6):538–548. doi: 10.1038/bjc.1974.233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wenk E. J., Orlic D., Reith E. J., Rhodin J. A. The ultrastructure of mouse lymph node venules and the passage of lymphocytes across their walls. J Ultrastruct Res. 1974 May;47(2):214–241. doi: 10.1016/s0022-5320(74)80071-7. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES