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Those taking Protandim® for 88 days (n = 8) showed a 2-fold higher increase in SOD compared to the 11 runners taking the placebo (Group x Time interaction effect, p = 0.038). The effect size for the between group change between Protandim® and placebo was +1.00 (Bias corrected, Hedges) (95% CI of the effect size = 0.03 to 1.96) in favor of Protandim®.
