Fig. 6.

Photodynamic therapy with iron oxide nanoparticles conjugated with photosensitizing agent Ce6. (a) A schematic drawing to illustrate in vivo magnetic tumor targeting. (b) In vivo fluorescence image of a 4T1 tumor bearing mouse. (c) In vivo T₂-weighted MR images of a mouse taken before injection (upper) and 24 h post injection (bottom). White and red arrows point to tumors without and with a magnet attached, respectively. (d) Ce6 fluorescence signal intensities in magnetic field (MF) targeted and non-targeted tumor regions. (e) T₂-weighted MR signals of untreated, MF targeted and non-targeted tumors. (f) Tumor growth curves of different groups of tumors after various treatments indicated. Error bars were based on SD of six tumors per group. MF: magnetic field; L: light. (g) Representative photos of mice after various treatments. White and red arrows point to tumors without and with magnetic targeting, respectively. Adapted from Ref.⁹⁵ with permission from The Royal Society of Chemistry.