Skip to main content
. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: J Neurosci Res. 2015 Nov 3;94(3):207–230. doi: 10.1002/jnr.23685

Figure 2. Model for Ca2+-dependent, vesicle-mediated sealing in which vesicles form a plug at a partly constricted cut end and sites of minor plasmalemmal damage in all eukaryotic cells.

Figure 2

Modified and used with permission from Spaeth et al., 2010, 2012a,b,c.

PKA, PKC: phosphokinase A or C, Epac: exchange protein activated by cAMP, DAG: diacyl-glycerol. PEG bypasses all endogenous sealing pathways and induces sealing of small holes or complete transection within a fraction of a second by collapse and fusion of plasmalemmal leaflets to produce “PEG-Sealing”.