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. Author manuscript; available in PMC: 2017 Aug 27.
Published in final edited form as: Nat Prod Rep. 2016 Jul 4;33(8):942–950. doi: 10.1039/c6np00024j

Fig. 1.

Fig. 1

A comparison of two different workflows for natural products discovery. Structure-based discovery (bottom) emphasizes the use of spectrometric data early in the pipeline to quickly dereplicate known compounds and scaffolds, allowing researchers to save resources and focus on unknown compounds.