Table 2.

Association of Well-Controlled HIV Infection with Complement Activation and Function and IgG Levels

	HIV + (mean ± SD)	HIV − (mean ± SD)	Unadjusted p value	Adjusted p value
C5a (ng/mL)	73 ± 31	87 ± 33	0.02	0.09
C3a (ng/mL)	8059 ± 7632	4901 ± 2240	<0.0001	0.06
CH50 (U/mL)	46 ± 8	42 ± 6	0.0006	0.2
IgG1 (µg/mL)	8811 ± 5942	6760 ± 3268	0.004	0.5
IgG2 (µg/mL)	1960 ± 1278	2361 ± 1330	0.10
IgG3 (µg/mL)	1955 ± 984	1433 ± 660	0.0003	0.04
IgG4 (µg/mL)	357 ± 356	481 ± 296	0.07	0.2
Total IgG (µg/mL)	13082 ± 6891	11035 ± 3906	0.02	0.6

Covariates were included in the multivariate model if they were significant on univariate analysis. Multivariate models included age and HCV infection for C5a; HCV infection for C3a; age, race, HCV infection, and statin use for CH50; race for IgG1, nothing for IgG2 (no covariates were significant on univariate analysis); age and HCV infection for IgG3; smoking status for IgG4; and race for IgG total.