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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Mov Disord. 2016 Apr 29;31(8):1140–1141. doi: 10.1002/mds.26647

Figure 1.

Figure 1

A) Threonine or serine residues in Rab receptacles that depend on LRRK2 kinase activity for their phosphorylated state in cells. B) Rabs with serine in switch II residues may not serve as efficient LRRK2 kinase substrates for LRRK2 in vitro but are regulated by LRRK2 in cells. Rabs with threonine residues in switch II may serve as direct LRRK2 kinase substrates both in vitro and in cells. Blue arrows indicate relative strength of LRRK2-mediate phosphorylation of the switch II receptacles.