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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: J Neurosci Methods. 2016 Jun 16;270:124–131. doi: 10.1016/j.jneumeth.2016.06.012

Figure 5. Vascular density is decreased in metastatic lesions compared to normal brain parenchyma regardless of location.

Figure 5

Representative fluorescence images of GFP (left panel), ICG (center panel), and overlay (right panel) in normal brain (row A), metastatic tumor (row B), and RG2 glioma regions (row C). GFP labelled metastases (M) or glioma (G) are shown with adjacent tissue separated by white dashed lines. Scale bars = 200μm. (D) Vascular density of cortex and metastases (1st and 2nd column) in corresponding cortex region. The 3rd–5th columns show vascular density of cuadate-putamen, metastastes, and glioblastoma in corresponding brain region (caudate-putamen). Statistical significance in cortical samples was determined using Student’s t-test; ***p < 0.001, n=3–5. Significance in caudate putamen region was determined using ANOVA with Bonferroni’s multiple comparison’s test; *** p < 0.0001, n=3–5.