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. Author manuscript; available in PMC: 2016 Aug 31.
Published in final edited form as: Cell Rep. 2016 Jul 28;16(6):1653–1663. doi: 10.1016/j.celrep.2016.06.101

Figure 1. Altering adult hippocampal expression of miR-17-92 in miR-17-92 KO and OE mice.

Figure 1

(A) Schematic genomic organization of miRNAs in the miR-17-92 cluster on mouse chromosome 14. The color code represents miRNAs with the conserved seed sequence.

(B) miR-17 (miR-20a), miR-19a (miR-19b) and miR-92a were expressed in the 12 weeks old adult mouse hippocampus (Hp) and cortex (Cx).

(C and D) Generation of miR-17-92 knockout (KO) and miR-17-92 overexpressing (OE) mice using the Nestin-CreER line.

(E) The whole brain images of wild type (WT), miR-17-92 KO, and miR-17-92 OE mice at the age of 13 weeks old.

(F) The body weight of miR-17-92 KO was slightly reduced, and the body weight of miR-17-92 OE mice was not changed, compared to WT controls. Brain weights of miR-17-92 KO and miR-17-92 OE mice were indistinguishable from WT controls.

Values plotted were means ± s.e.m. n=6 mice per group. *: p < 0.05. A two-tailed, unpaired Student’s t-test was used for comparisons. See also Figures S1 and S2.