Figure 1.
A Representative HGPIN lesion (P) from radical cystoprostatectomy with adjacent benign glandular epithelium (B) (200× magnification). B: prominent nucleoli are apparent in HGPIN cells (P) compared to adjacent benign luminal cells (B) (630× magnification). C: Immunostaining for ERG is negative in HGPIN (P) and benign (B) glands, with positive staining in adjacent endothelial nuclei as an internal positive control (200× magnification). D: PTEN immunostaining is intact in HGPIN (P) lesion and adjacent benign (B) glands (200× magnification).