Table 1.
A Race-Specific Model of Effect Site Compartment EC05, EC50, EC95 Propofol Concentrations Predicted by the Marsh Diprifusor Model Corresponding to Loss of Consciousness.
| Race Location Sample size |
ESC
EC05 (95%CI) (µg/mL) |
ESC
EC50 (95%CI) (µg/mL) |
ESC
EC95 (95%CI) (µg/mL) |
ESC EC50 X/Cauc. Cauc./X |
Pla.
EC05 (95%CI) (µg/mL) |
Pla.
EC50 (95%CI) (µg/mL) |
Pla.
EC95 (95%CI) (µg/mL) |
Source Year of Publication |
|---|---|---|---|---|---|---|---|---|
| Indians Chandigarh n=18 |
1.38 (-) |
1.88 (1.87–1.91) |
2.37 (2.37–2.38) |
0.67 1.5 |
1.88 from Puri Fig. 1 | 2.31 (2.16–2.45) |
2.8 (2.61–3.19) |
Puri et al. [7] 2011 (adapted) |
| Blacks UK n=50 |
1.08 (-) |
2.02 (-) |
2.95 (-) |
0.72 1.4 |
- | - | - | Natarajan et al. [6] 2011 (adapted) |
| Chinese Beijing n=405 | 1.3 (1.2–1.4) |
2.2 (2.2–2.3) |
3.2 (3.1–3.3) |
0.8 1.3 |
2.9 (2.7–3.0) |
3.8 (3.8–3.9) |
4.8 (4.7–4.9) |
Xu et al. [16] 2009 |
| Caucasians Glasgow n=40 | 1.5 (1.3–1.7) |
2.8 (2.7–2.9) |
4.1 (3.9–4.3) |
1.0 1.0 |
3.1 (2.6–3.5) |
5.2 (5.0–5.4) |
7.3 (7.0–7.8) |
Milne et al. [9] 2003 |
| Chinese Hong Kong n=60 |
1.89 (-) |
2.66 (2.59–2.72) |
3.82 (3.68–4.00) |
- |
2.98 (-) |
3.92 (3.8–4.04) |
5.38 (5.16–5.66) |
Irwin et al. [8] 2002 |
| Chinese Zhejiang n=30 | - | 1.6 ±
0.4 (mean±sd) Not EC50 |
- | - | - | - | - | Dahaba et al. [17] 2011 |
| Caucasians Austria n=30 | - | 2.4 ±
1.5 (mean±sd) Not EC50 |
- | - | - | - | - | Dahaba et al. [17] 2011 |
ESC, effect site compartment; Pla., plasma (central) compartment; Cauc., Caucasian.
All studies used the Marsh Diprifusor TCI software v 2.0 except Puri (Marsh TCI Diprifusor of unspecified version) and Natarajan (non-TCI pump). EC values in italics mean they are adapted from the literature. The bottom 3 rows present results from studies that were not used to create the proposed model.