Table 1: Comparison of various physical parameters of three generic and one branded travoprost formulations

Drug

Drug concentration (mean ± SD)

Drug formulations

(Preservative)

% purity

(μg/mL)

(μg/drop)

Amount of solution per bottle (mL) (mean ± SD)

Drop Size (μL) (mean ± SD)

Osmolality (mOsm) (mean ± SD)

pH (mean ± SD)

Specific gravity (mean ± SD)

TP1 (Travo)

Ionic buffer system with boron polyoxol complex

0.0037± 0.0031 (91.79±7.89)

36.21 ±0.86

1.42±0.02

3.38±0.06

38.9±3.2

313.0±1.0

5.9±0.0

1.00±0.003

TP2 (Tovaxo)

Benzalkonium chloride (0.015%)

0.0056±0.0002 (140.4±6.3)

56.62±0.40

1.44±0.01

2.58±0.15

25.8±3.7

262.0±1.0

4.7±0.25

0.99±0.005

TP3 (Xovatra)

Isotonic buffered aqueous vehicle preserved with ionic buffer system

0.0034±0.0003 (86.71 ±8.072)

34.51 ±0.61

1.02±0.01

3.13±0.28

29.7±3.3

305.3±3.0

5.7±0.26

(0.99±0.000)

TP4 (Travatan)

Polyquaternium-1

0.0038±0.0005 (95.37± 13.34)

38.14±1.05

1.01 ±0.00

3.00±0.33

26.5±4.3

308.0±1.7

5.8±0.06

0.99±0.003

Overall between

0.000*

0.000*

0.000*

0.000*

0.000*

0.000*

0.000*

0.000*

group p-value

Posthoc analysis

TP1 vs TP4

0.723

0.000*

0.000*

0.000*

0.000*

0.000*

0.745

0.000*

p-value

TP2 vs TP4

0.000*

0.000*

0.000*

0.000*

0.591

0.000*

0.000*

0.000*

TP3 vs TP4

0.111

0.000*

0.068

0.274

0.006*

0.001*

0.645

0.001

*p<0.05, statistically significant