TABLE 1.
Some moonlighting proteins in yeasts
| Protein | Canonical function | Moonlighting activity | Yeast species | Reference(s) |
|---|---|---|---|---|
| Homocitrate synthase | Acyl transferase (lysine biosynthesis) | Repair of damaged DNA | S. cerevisiae | 29, 32 |
| Superoxide dismutase | Conversion of superoxide radical into O2 and H2O2 | Regulation of genes related to oxidative stress | S. cerevisiae | 42 |
| Pyruvate decarboxylase | Pyruvate decarboxylation (glycolysis) | Regulation of PDC1/PDC5 transcription | S. cerevisiae, K. lactis | 47, 49, 50, 52 |
| Zuotin | Molecular chaperone | Activation of pleiotropic drug resistance | S. cerevisiae | 58, 60, 64 |
| Subunit Sdh3 of succinate dehydrogenase | Oxidation of succinate (citric acid cycle), electron transport | Assembly of mitochondrial translocase | S. cerevisiae | 70 |
| Enolase | Dehydration of 2-P-glycerate (glycolysis) | Binding to plasminogen | C. albicans | 79 |
| Phosphate-glycerate mutase | Isomerization of 3-P-glycerate (glycolysis) | Binding to plasminogen and to complement regulators | C. albicans | 78, 81 |
| Glycerol-3-phosphate dehydrogenase | Reduction of dihydroxyacetone phosphate to glycerol-3-phosphate (ancillary to glycolysis) | Binding to plasminogen and to complement regulators | C. albicans | 84 |
| Hgt1 | Glucose transporter (glycolysis) | Binding to complement regulators | C. albicans | 90 |
| Hal3 | Decarboxylation of phosphate-pantothenoyl–l-cysteine (CoA biosynthesis) | Inhibitor of phosphatases Ppz1 and Ppz2 | S. cerevisiae, S. pombe | 95, 99 |
a
Shown are the moonlighting proteins considered in the text. A table with other moonlighting proteins from yeasts is presented in reference 22.