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There are two types of ET receptors: ETA and ETB. ETA receptors are found on the vascular smooth muscle and are vasoconstrictor. ETB receptors are identified as ETB1 and ETB2 based upon pharmacological response to RES701. RES701 was found to block ETB1 (located on vascular endothelial cells and function as dilator) but not ETB2 (located on vascular smooth muscle cells and function as constrictor).
