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Change of symptoms related to pleural effusion at the close-out visit. In the evaluation for change of clinical symptoms conducted at the close-out visit, the proportion of patients without symptom was increased from 31.9% to 80.7%, and the proportion of dyspnea, cough, and pleurodynia was decreased from 48.4% to 16.1%, from 11.3% to 1.6%, and from 22.6% to 3.2%, respectively.
