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. 2016 Aug 12;6:31316. doi: 10.1038/srep31316

Table 3. Gene expression in amino acid and cell division pathways in A. borkumensis SK2 cells grown under 10 MPa as compared to 0.1 MPa.

Pathway Regulation log2 FC 10 MPa 0.1 MPa Cluster ID Locus Tag Description
Glycine, Serine and Threonine Metabolism
  + 1.97 337.3 86.4 1005 ABO_2594 glycine cleavage system T protein
  + 1.37 590.4 228.6 1355 ABO_0807 threonine synthase
  + 1.22 125.4 53.9 222 ABO_2176 serine hydroxymethyltransferase
  + 0.79 160.3 93.0 1666 ABO_2593 glycine cleavage system H protein
  + 0.76 136.6 80.6 709 ABO_2442 phosphoserine phosphatase
  + 0.71 135.0 82.4 1054 ABO_0806 homoserine dehydrogenase
  + 0.51 147.1 103.5 360 ABO_1769 phosphoglycerate mutase
  = 0.46 40.7 29.5 136 ABO_2592 glycine dehydrogenase subunit 1
  = 0.45 127.7 93.7 223 ABO_0688 TRAP dicarboxylate transporter
  = 0.3 24.3 19.8 1494 ABO_2591 glycine dehydrogenase subunit 2
  = 0.18 92.3 81.4 149 ABO_1436 phosphoserine phosphatase
  = -0.02 169.2 171.2 1271 ABO_0042 phosphotransferase family protein
  = −0.08 282.6 298.4 1943 ABO_1494 2-oxoglutarate dehydrogenase lipoamide
  = −0.23 89.2 104.5 490 ABO_2605 threonine dehydratase, biosynthetic
  = −0.23 89.2 104.5 490 ABO_2605 threonine dehydratase, biosynthetic
  − −0.61 76.1 116.1 1056 ABO_1750 phosphoserine aminotransferase
L-leucine Biosynthesis
  + 4.91 3676.8 122.4 510 ABO_2437 ilvE; branched-chain amino acid aminotransferase
  + 2.45 159.5 29.2 1318 ABO_2301 ilvE; branched-chain amino acid aminotransferase
  + 1.53 833.4 289.3 2145 ABO_1470 leuC; isopropylmalate isomerase large subunit
  + 1.00 674.3 337.8 559 ABO_0482 ilvH; acetolactate synthase 3 regulatory subunit
  + 0.81 122.0 69.5 1715 ABO_0481 ilvB-1; acetolactate synthase 3 catalytic subunit
  = 0.39 215.5 164.5 595 ABO_0485 ketol-acid reductoisomerase
  = 0.27 43.4 36.0 394 ABO_2312 dihydroxy-acid dehydratase
  = 0.23 272.9 232.5 339 ABO_1467 3-isopropylmalate dehydrogenase
  = 0.20 436.2 378.6 1492 ABO_1469 3-isopropylmalate dehydratase small subunit
  = 0.11 86.9 80.3 1428 ABO_0638 2-isopropylmalate synthase
Valine, Leucine and Isoleucine Biosynthesis
  + 4.91 3676.8 122.4 510 ABO_2437 2-isopropylmalate synthase
  + 2.45 159.5 29.2 1318 ABO_2301 branched-chain amino acid aminotransferase
  + 1.53 833.4 289.3 2145 ABO_1470 isopropylmalate isomerase large subunit
  + 1 674.3 337.8 559 ABO_0482 acetolactate synthase 3 regulatory subunit
  + 0.81 122.0 69.6 1715 ABO_0481 acetolactate synthase 3 catalytic subunit
  = 0.39 215.5 164.5 595 ABO_0485 ketol-acid reductoisomerase
  = 0.27 43.4 36.0 394 ABO_2312 dihydroxy-acid dehydratase
  = 0.23 272.9 232.5 339 ABO_1467 3-isopropylmalate dehydrogenase
  = 0.2 436.2 378.6 1492 ABO_1469 3-isopropylmalate dehydratase small subunit
  = 0.11 86.9 80.3 1428 ABO_0638 2-isopropylmalate synthase
  = −0.23 89.2 104.5 490 ABO_2605 threonine dehydratase, biosynthetic
  − −0.53 62.3 89.9 1571 ABO_0180 dihydroxy-acid dehydratase
  − −0.78 46.8 80.4 2136 ABO_0704 acetolactate synthase
Cell division
  + 1.44 461.9 170.6 1439 ABO_0591 cell division protein FtsL
  + 0.78 287.3 166.8 1367 ABO_0948 cell division protein ZipA
  + 0.75 69.9 41.5 2142 ABO_2566 cell division protein FtsY
  = 0.36 165.4 128.5 778 ABO_1290 cell division protein FtsK
  = −0.07 843.5 882.6 1176 ABO_0322 cell division protein FtsH
  = −0.07 65.9 69.4 2138 ABO_0603 cell division protein FtsZ
  − −0.86 15.1 27.5 1319 ABO_2568 cell division protein FtsX
  − −0.91 52.6 98.8 1374 ABO_0601 cell division protein FtsQ
  − −0.94 88.6 169.5 539 ABO_0597 cell division protein FtsW
  − −1.05 13.4 27.8 1874 ABO_2567 cell division ATP-binding protein FtsE
  − −1.66 34.0 107.6 449 ABO_0602 cell division protein FtsA