Figure 3. (+)-Phendimetrazine (PDM) effects on either dopamine- (DA) or (+)-phenmetrazine (PM) -induced inward currents at hDAT in Xenopus laevis oocytes voltage-clamped to −60 mV.

Panel A shows application of 1 μM β-CIT (positive control) blocked the hDAT current induced by 5 μM (+)-phenmetrazine. Panel B shows application of 100 μM (+)-PM attenuated the current induced by 2 μM (+)-PM. Panel C shows application of 100 μM (+)-PDM also attenuated the current induced by 2 μM DA. For all panels, the initial DA-induced response was 5 μM DA.