Fig.2.

Sideritis spp. potently reduce neurotoxic brain Aβ₄₂ levels and protect from neuronal loss. A) S. scardica, S. euboea, and the extract combination reduce buffer-soluble Aβ₄₂ significantly in both treatment strategies. B) Quantification of neuronal area indicated significant neuron loss in vehicle-treated APP-tg mice in comparison to vehicle-treated, non-transgenic littermates. A significantly increased neuronal area of Sideritis spp.-treated APP-tg mice compared to vehicle treated APP-tg mice indicates neuroprotective effects of the Sideritis spp. extract combination in both paradigms (mean + SEM, *p≤0.05). C, D) Microphotographs of NeuN stained brain slices of APP-tg mice after (C) vehicle treatment and (D) post-AD-onset therapy with Sideritis spp. extract combination (scale bars: 50μm).