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. 2015 Nov 17;34(2):418–430. doi: 10.1002/stem.2241

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© 2016 The Authors STEM CELLS published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Wnt stimulation increases STRO‐1 proliferation and protects from apoptosis and necrosis. (A): Wnt3A had no effect on the total cell numbers after 24 hours of suspension culture (n = 10). (B): Wnt stimulation had no effect on the proportion of the populations of lymphocytes, granulocytes and monocytes in bone marrow mononuclear cells (BMMNC) isolates (n = 11). (C): Wnt has no effect on blood cell lineages. Representative figures from triplicates from one patient. (D): Wnt stimulation induces an increase in the frequency of proliferating (EdU⁺) cells within the STRO‐1⁺ population but has no effect on the proportion of EdU⁺ within other populations (E). (F): Wnt stimulation causes an increase in cell viability and a decrease in apoptosis and necrosis (stained with Annexin V and 7‐AAD) within the STRO‐1⁺ population. Data in (D), (E), and (F) presented as mean ± SD, n = 1 donor.