Table 2.

Effects of RFA on the progression of residual HCC in VX2 rabbit model of liver cancer

Animal model	Treatment	Effects on the progression of residual HCC	References
Rabbit VX2 HCC model	RFA at different temperatures (55,70 and 85 °C)	Low temperatures induce rapid progression of residual HCC. Tumor progression is associated to PCNA, MMP-9, and VEGF, HGF and IL-6 overexpression.	[18]
Rabbit VX2 HCC model	Aspirin, RFA	Reduced progression of residual HCC associated to reduced inflammation.	[21]