Table 3.

Axis loadings for principal components analysis of tier 2 KO functions

Wild fish		Laboratory-housed fish
Axis 1	Axis 2	Axis 1	Axis 2
Positive	Positive	Positive	Positive
o Xenobiotics biodegradation and metabolism o Metabolism of terpenoids and polyketides o Lipid metabolism	o Signal transduction o Cellular processes and signaling o Metabolism of other amino acids	o Carbohydrate metabolism o Nucleotide metabolism o Replication and repair	o Lipid metabolism o Metabolism of terpenoids and polyketides o Xenobiotics biodegradation and metabolism
Negative	Negative	Negative	Negative
o Membrane transport o Transcription	o Carbohydrate metabolism o Translation	o Transcription o Cellular processes and signaling	o Amino acid metabolism o Enzyme families

Factors shown had the five largest loadings and were ≥ 1 % of inferred function