Table 1.

Event Summary by Randomly Assigned Regimen

	Methotrexate Regimen				Corticosteroid Regimen
Event	C-MTX	HD-MTX	P*	Total	Dex	Prednisone	P*	Total
None	993	1,036	.02	2,029	747	735	.38	1,482
Induction failure	58	52	.58	110	32	38	.48	70
Induction death	24	24	.98	48	18	17	.85	35
Relapse
Marrow	104	82	.10	186	80	74	.59	154
CNS	49	34	.10	83	27	39	.14	66
Testicular	3	4	.70	7	4	2	.41	6
Combined + other	27	16	.10	43	19	20	.88	39
Second malignant neoplasm	8	10	.63	18	5	11	.13	16
Death	25	24	.90	49	15	16	.87	31

Abbreviations: C-MTX, Capizzi escalating-dose methotrexate; Dex, dexamethasone; HD-MTX, high-dose methotrexate.

^*χ² test.