Table 4.
Combined effects of miR-605 rs2043556 and miR-196a2 rs11614913 on oral squamous cell carcinoma (OSCC) risk
| Number of risk allelesa | Patients [number (%)] | Controls [number (%)] | Adjust OR (95% CI)b | P b |
|---|---|---|---|---|
| 0–1 | 66 (14.3) | 303 (19.6) | 1.00 | |
| 2 | 153 (33.2) | 575 (37.2) | 1.20 (0.87–1.66) | 0.262 |
| 3 | 168 (36.4) | 517 (33.4) | 1.51 (1.10–2.09) | 0.011 |
| 4 | 74 (16.1) | 151 (9.8) | 2.23 (1.51–3.29) | <0.001 |
| Trend | NA | NA | 1.21 (1.10–1.32) | <0.001 |
| Binary classification | <0.001 | |||
| 0–2 | 219 (47.5) | 878 (56.8) | 1.00 | |
| 3–4 | 242 (52.5) | 668 (43.2) | 1.48 (1.20–1.83) | |
Italic value indicate significance of p value (p < 0.05)
aThe miR-605 rs2043556 A and miR-196a2 rs11614913 G allele were assumed as risk alleles based on the main effect of the individual locus and were genotyped in the 461 OSCC cases and 1546 controls
bAdjusted by age, sex, smoking status, and drinking status