Table 2.
Clinicopathologic characteristics of 120 septic patients with genetic variants in the prolyl-hydroxlase 2 gene (SNP rs516651)
| PHD2 CC | PHD2 CT | PHD2 TT | p-value | |
|---|---|---|---|---|
| n = 96 | n = 21 | n = 3 | ||
| Patients characteristics | ||||
| Gender (women/men; %) | 38/58 (39.6/60.4) | 5/16 (23.8/76.2) | 1/2 (33.3/66.7) | 0.094** |
| age (years; median; Q1; Q3)b | 55 (44–68) | 58 (53–65) | 71 (50–71) | 0.201* |
| height (cm; median; Q1; Q3)b | 172 (165–180) | 179 (170–184) | 185 (156–185) | 0.342* |
| body weight (kg; median; Q1; Q3)b | 80 (65–90) | 90 (77–110) | 78 (75–78) | 0.205* |
| BMI (kg/m2; median; Q1; Q3)b | 26.2 (22.8–30.8) | 28.1 (25.3–34) | 26.3 (22.8–26.3) | 0.434* |
| Heart rate (min−1; median, Q1; Q3)b | 100 (90–121) | 113 (94–156) | 90 (70–90) | 0.063* |
| Mean arterial blood pressure (mmHg; median; Q1; Q3)b | 75 (63–87) | 73 (61–87) | 76 (63–76) | 0.850* |
| creatinin serum concentration (mg dl−1; (median; Q1;Q3)b | 1.66 (0.97–2.85) | 1.73 (0.96–2.08) | 1.16 (1.15–1.16) | 0.874* |
| Dialysis (yes/no; %) | 62/34 (64.6/35.4) | 14/6 (70/30) | 3 (100) | 0.619** |
| Primary diagnoses % | ||||
| Cardiovascular disease | 5 (6.2) | 2 (11.1) | 1 (33.3) | c |
| Hematooncological disease | 3 (3.7) | 2 (11.1) | ||
| Gastrointestinal disease | 33 (40.7) | 4 (22.2) | ||
| Lung disease | 19 (23.5) | 5 (27.8) | 1 (33.3) | |
| Urogenital cancer | 6 (7.4) | 1 (5.6) | ||
| Intraabdominal pathology, other Cancer, other | 15 (18.4) | 4 (22.2) | 1 (33.3) | |
| Infectious variables | ||||
| White blood cell count (109 l−1; median; Q1; Q3)b | 13.8 (9.3–20.6) | 15.5 (8.9–19.1) | 15.6 (12.2–15.6) | 0.961* |
| Procalcitonin concentration (μg l−1; median; Q1; Q3)b | 3.97 (1.2–15.7) | 3.46 (0.31–9.93) | 0.5 (0.23–0.5) | 0.699* |
| C-reactive protein concentration (g l−1; median; Q1; Q3)b | 17.7 (9.1–27.3) | 15 (8–21.5) | 18.4 (0.5–18.4) | 0.603* |
| Disease severity | ||||
| SAPS IId (mean ± SD)a | 35 (27–44) | 38 (30–50) | 48 (41–48) | 0.107* |
| Hospital stay (d; mean ± SD)a | 23 (12–35) | 29 (11–56) | 21 (9–21) | 0.071* |
| 30-day mortality (%) | 33 (34.4) | 8 (38.1) | 2 (66.7) | 0.103** |
Biometric data, primary diagnoses, infectious variables, and disease severity of 120 septic patients. Data were documented at the time of first diagnosing sepsis
*Numbers; p-value based on One-Way-ANOVA;
**Numbers; p-value based on Pearson-Chi-quadrat tests
amean ± standard deviation
bmedian with 25 and 75 % quartiles (median; Q1; Q3);
cno statistical test has been applied here
dSimplified Acute Physiology Score II