Table 3.
Clinicopathologic characteristics of septic patients with genetic variants in the prolyl-hydroxlase 2 gene (SNP rs480902)
| PHD2 CC | PHD2 CT | PHD2 TT | p-value | |
|---|---|---|---|---|
| n = 72 | n = 44 | n = 12 | ||
| Patients characteristics | ||||
| Gender (women/men; %) | 23/49 (31.9/68.1) | 14/30 (31.8/68.2) | 7/5 (58.3/41.7) | 0.185** |
| age (years; median; Q1; Q3)b | 58 (45–70) | 54.5 (46–65) | 67 (55–78) | 0.111* |
| height (cm; median; Q1; Q3)b | 174 (165–180) | 178 (169–182) | 165 (160–175) | 0.122* |
| body weight (kg; median; Q1; Q3)b | 80 (70–90) | 85 (65–96) | 80 (70–86) | 0.455* |
| BMI (kg/m2; median; Q1; Q3)b | 26.2 (22.9–30.5) | 27.8 (22.8–33) | 27.8 (24–30.8) | 0.759* |
| Heart rate (min−1; median, Q1; Q3)b | 101 (92–124) | 110 (92–135) | 96 (72–125) | 0.753* |
| Mean arterial blood pressure (mmHg; median; Q1; Q3)b | 76 (63–88) | 73 (63–87) | 70 (54–87) | 0.484* |
| creatinin serum concentration (mg dl−1; (median; Q1;Q3)b | 1.45 (1.0–3.0) | 1.48 (1.0–2.1) | 1.95 (1.0–2.4) | 0.506* |
| Dialysis (yes/no; %) | 48/23 (67.6/32.4) | 30/14 (68.2/31.8) | 6/6 (50/50) | 0.468** |
| Primary diagnoses % | ||||
| Cardiovascular disease | 4 (6.5) | 5 (13.2) | 1 (10) | c |
| Hematooncological disease | 4 (6.5) | 2 (5.3) | 1 (10) | |
| Gastrointestinal disease | 22 (35.5) | 10 (26.3) | 5 (50) | |
| Lung disease | 13 (20.9) | 12 (31.5) | 1 (10) | |
| Urogenital cancer | 6 (9.7) | 2 (5.3) | 0 | |
| Intraabdominal pathology, other Cancer, other | 13 (20.9) | 7 (18.4) | 5 (20) | |
| Infectious variables | ||||
| White blood cell count (109 l−1; median; Q1; Q3)b | 15.0 (9.7–20.9) | 12.1 (8.1–18.3) | 12.3 (8.9–21.2) | 0.632* |
| Procalcitonin concentration (μg l−1; median; Q1; Q3)b | 3.6 (1.0–22.2) | 3.5 (1.0–11.5) | 14.9 (0.7–18.7) | 0.789* |
| C-reactive protein concentration (g l−1; median; Q1; Q3)b | 17.2 (8.6–23.9) | 15.2 (9.7–24.7) | 22.9 (7.2–39.4) | 0.155* |
| Disease severity | ||||
| SAPS IId (mean ± SD)a | 37 (29–45) | 37 (27–49) | 37 (25–51) | 0.941* |
| Hospital stay (d; mean ± SD)a | 26 (10–44) | 17 (12–31) | 23 (12–33) | 0.121* |
| 30-day mortality (%) | 27 (37.5) | 18 (40.9) | 4 (33.3) | 0.876** |
Biometric data, primary diagnoses, infectious variables, and disease severity of 128 septic patients. Data were documented at the time of first diagnosing sepsis
*Numbers; p-value based on One-Way-ANOVA;
**Numbers; p-value based on Pearson-Chi-quadrat tests
amean ± standard deviation
bmedian with 25 and 75 % quartiles (median; Q1; Q3);
cno statistical test has been applied here
dSimplified Acute Physiology Score II