Table 1.

OMIM Disease Subnetworks

	Number of disease subnetworks
	PINA network		PINAmin2 network
Size of disease		Permutation		Permutation
subnetwork	Observed	average	Observed	average
2	124	12.54 ± 3.35	61	3.46 ± 1.93
3	27	1.65 ± 1.25	11	0.44 ± 0.73
4	11	0.40 ± 0.60	7	0.06 ± 0.25
5+	10	0.28 ± 0.49	5	0.07 ± 0.26
Total	172	14.87 ± 3.46	84	4.03 ± 2.13

Observed = number of disease subnetworks of given size induced by a single disease term in the original network; Permutation average = average number of disease subnetworks of given size induced by a single disease term across 10,000 randomly permuted networks (mean ± standard deviation).