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. 2015 Oct 7;36(12):1135–1144. doi: 10.1002/humu.22906

Table 1.

OMIM Disease Subnetworks

Number of disease subnetworks
PINA network PINAmin2 network
Size of disease Permutation Permutation
subnetwork Observed average Observed average
2 124 12.54 ± 3.35 61 3.46 ± 1.93
3 27 1.65 ± 1.25 11 0.44 ± 0.73
4 11 0.40 ± 0.60 7 0.06 ± 0.25
5+ 10 0.28 ± 0.49 5 0.07 ± 0.26
Total 172 14.87 ± 3.46 84 4.03 ± 2.13

Observed = number of disease subnetworks of given size induced by a single disease term in the original network; Permutation average = average number of disease subnetworks of given size induced by a single disease term across 10,000 randomly permuted networks (mean ± standard deviation).