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Hepatocyte differentiation and expansion. Hepatocytes can be derived from human pluripotent stem cells (HLC) and via conversion of human somatic cells (hiHeps). Hepatocytes can also be expanded from primary human hepatocytes (PHH) using cell transformation techniques and small molecules. Abbreviations: hESC, human embryonic stem cell; hiPSC, human induced pluripotent stem cell; PHH: primary human hepatocytes.
