Figure 2.

Regulation of T‐cell development by medullary thymic epithelial cell (m TEC ). Although the majority of thymocytes that reside within the thymic medulla are of the conventional αβT‐cell lineage, several studies have now revealed the importance of this microenvironment in the generation of other thymus‐dependent T‐cell subsets. However, in most cases, the precise mTEC compartments that regulate development of their development are not fully understood. Of note, these T‐cell sub‐lineages represent components of both the innate and adaptive immune systems, and their development within the thymus has also been shown to be linked to mTEC development, indicating the importance of reciprocal interactions between multiple T‐cell subsets and mTEC progenitors for medulla formation.