Table 4.

Malaria incidence

	Malaria episodes	Person‐years	Incidence ratea	Hazard ratio (95% CI)	P‐value	Adjusted hazard ratio (95% CI)	P‐value
SMC period
All children
AL group	72	314.0	229.3	[reference]	–	[reference]	–
DP	90	318.9	282.2	1.23 (0.87, 1.73)	0.234	1.18 (0.83, 1.67)	0.356
SMC	45	317.2	141.9	0.62 (0.41, 0.92)	0.019	0.62 (0.41, 0.93)	0.020
Received five rounds
AL only	41	137.6	298.0	[reference]	–	[reference]	–
DP	54	139.7	386.4	1.29 (0.82, 2.05)	0.274	1.16 (0.72, 1.87)	0.540
SMC	19	122.6	155.0	0.52 (0.29, 0.92)	0.026	0.53 (0.29, 0.95)	0.033
Post‐SMC period
All children
AL only	31	309.6	100.1	[reference]	–	[reference]	–
DP	52	305.2	170.4	1.70 (1.01, 2.86)	0.045	1.34 (0.86, 2.10)	0.199
SMC	52	301.4	172.5	1.73 (1.00, 2.99)	0.050	1.36 (0.86, 2.14)	0.187
Received five rounds
AL only	23	152.6	150.7	[reference]	–	[reference]	–
DP	37	153.0	241.8	1.61 (0.87, 3.00)	0.131	1.22 (0.75, 1.98)	0.418
SMC	38	128.6	295.6	1.97 (1.04, 3.73)	0.038	1.44 (0.86, 2.42)	0.166
Whole study period
All children
AL only	103	623.6	165.2	[reference]	–	[reference]	–
DP	142	624.1	227.5	1.37 (1.00, 1.88)	0.047	1.23 (0.92, 1.65)	0.168
SMC	97	618.5	156.8	0.95 (0.67, 1.33)	0.755	0.88 (0.65, 1.20)	0.428
Received five rounds
AL only	64	290.2	220.6	[reference]	–	[reference]	–
DP	91	292.8	310.8	1.41 (0.93, 2.14)	0.108	1.20 (0.83, 1.74)	0.337
SMC	57	251.1	227.0	1.03 (0.65, 1.62)	0.913	0.91 (0.62, 1.35)	0.644

^aRate per 1000 person‐years. SMC period: From date of receipt of first SMC or placebo course, until 1 month after the last SMC course. Post‐SMC period: from 1 month after last SMC course until the end of the study.