Table 3.

Association estimates for NFκB-related polymorphisms and IA.

Variant_dbSNP	Gene	Effect-allele	OR (95% CI)a	Pvalue	OR (95% CI)b	Pvalue	OR (95% CI)c	Pvalue
rs4648110	NFκB1	A	0.69 (0.46–1.03)	0.07	0.73 (0.30–1.81)	0.50	0.74 (0.53–1.04)	0.08
rs12769316	NFκB2	A	0.87 (0.57–1.31)	0.50	0.79 (0.23–2.73)	0.70	0.87 (0.61–1.26)	0.48
rs1056890	NFκB2	T	1.41 (0.94–2.10)	0.10	1.01 (0.58–1.76)	0.96	1.19 (0.90–1.57)	0.23
rs11574851	NFκB2	T	1.52 (0.89–2.60)	0.13	1.47 (0.15–14.5)	0.74	1.46 (0.89–2.40)	0.14
rs842647	cREL	G	0.92 (0.63–1.34)	0.67	1.03 (0.50–2.14)	0.93	0.95 (0.71–1.29)	0.77
rs13017599	cREL	A	0.78 (0.54–1.13)	0.18	1.12 (0.67–1.88)	0.66	0.90 (0.69–1.18)	0.47
rs7119750	RELA	T	0.94 (0.61–1.46)	0.80	0.90 (0.19–4.26)	0.89	0.95 (0.64–1.41)	0.79
rs2288918	RELB	C	1.18 (0.80–1.73)	0.40	0.57 (0.30–1.09)	0.09	0.97 (0.73–1.28)	0.81
rs1877175	IRF4	A	0.82 (0.56–1.22)	0.34	0.59 (0.22–1.58)	0.30	0.82 (0.59–1.14)	0.24
rs1050975	IRF4	G	1.00 (0.61–1.63)	0.99	2.69 (0.75–9.61)	0.13	1.10 (0.72–1.68)	0.67
rs7768807	IRF4	C	1.33 (0.92–1.94)	0.13	1.26 (0.66–2.40)	0.48	1.24 (0.93–1.65)	0.14
rs12203592	IRF4	T	1.01 (0.66–1.53)	0.97	2.14 (0.64–7.19)	0.22	1.07 (0.74–1.56)	0.72

OR, odds ratio; CI, confidence interval; SNP, single nucleotide polymorphism. Estimates were adjusted for age, sex, country of origin, allo-SCT, and underlying disease. P < 0.0011 was defined as multiple testing significance threshold.

^aEstimates according to a dominant model of inheritance.

^bEstimates according to a recessive model of inheritance.

^cEstimates according to an additive model of inheritance.