Table 4.

Association estimates for NFκB-related polymorphisms and IA in HSCT patients (n = 239).

Variant_dbSNP	Gene	Effect-allele	OR (95% CI)a	Pvalue	OR (95% CI)b	Pvalue	OR (95% CI)c	Pvalue
rs4648110	NFκB1	A	1.04 (0.51–2.12)	0.92	2.99 (0.65–13.7)	0.16	1.19 (0.65–2.18)	0.57
rs12769316	NFκB2	A	1.29 (0.60–2.76)	0.51	NA (NA–NA)	NA	1.16 (0.57–2.37)	0.67
rs1056890	NFκB2	T	1.42 (0.67–3.00)	0.36	1.32 (0.44–3.96)	0.63	1.29 (0.75–2.24)	0.36
rs11574851	NFκB2	T	1.59 (0.56–4.53)*	0.38	NA (NA–NA)	NA	NA (NA–NA)	NA
rs842647	cREL	G	0.81 (0.40–1.64)	0.55	0.94 (0.23–3.74)	0.93	0.86 (0.48–1.53)	0.61
rs13017599	cREL	A	0.84 (0.42–1.68)	0.62	1.50 (0.61–3.67)	0.38	1.03 (0.63–1.68)	0.91
rs7119750	RELA	T	0.53 (0.22–1.24)	0.14	NA (NA–NA)	NA	0.52 (0.23–1.18)	0.12
rs2288918	RELB	C	1.17 (0.58–2.36)	0.66	0.86 (0.33–2.26)	0.76	1.04 (0.64–1.68)	0.88
rs1877175	IRF4	A	0.68 (0.32–1.44)	0.32	0.69 (0.08–6.00)	0.74	0.72 (0.37–1.40)	0.33
rs1050975	IRF4	G	0.65 (0.26–1.66)	0.37	2.60 (0.37–18.4)	0.34	0.84 (0.39–1.80)	0.66
rs7768807	IRF4	C	0.73 (0.35–1.51)	0.39	0.95 (0.30–3.03)	0.93	0.82 (0.47–1.44)	0.49
rs12203592	IRF4	T	1.04 (0.49–2.20)	0.91	6.24 (1.25–31.2)	0.026	1.33 (0.72–2.47)	0.36

OR, odds ratio; CI, confidence interval; SNP, single nucleotide polymorphism; NA, not applicable. Estimates were adjusted for age, sex, country of origin, and underlying disease. P < 0.05 in bold. P < 0.0011 was defined as multiple testing significance threshold.

^aEstimates calculated according to a dominant model of inheritance.

^bEstimates calculated according to a recessive model of inheritance.

^cEstimates calculated according to an additive model of inheritance.

^*Association estimates are referred to heterozygotes. Homozygotes for the rare allele were not found in the HSCT cohort.