Table 5.

Haplotype association analysis and risk of IA.

Overall population (N = 834)							HSCT population (N = 239)
NFκB2rs1056890	NFκB2rs11574851	NFκB2rs12769316		Freq	OR(95%CI)a	P-value	NFκB2rs1056890	NFκB2rs11574851	NFκB2rs12769316		Freq	OR(95%CI)b	P-value
C	C	G		0.4708	1.00	–	C	C	G		0.4827	1.00	–
T	C	G		0.3507	1.22 (0.91–1.64)	0.19	T	C	G		0.3443	1.58 (0.87–2.85)	0.13
C	C	A		0.1115	0.74 (0.45–1.23)	0.25	C	C	A		0.1106	1.45 (0.58–3.62)	0.43
C	T	A		0.0517	1.70 (0.99–2.90)	0.053	C	T	A		0.0458	2.26 (0.73–7.02)	0.16
RELrs842647	RELrs13017599			Freq	OR(95%CI)a	P-value	RELrs842647	RELrs13017599			Freq	OR(95%CI)b	P-value
A	G			0.3786	1.00	–	A	A			0.3685	1.00	–
A	A			0.3640	0.76 (0.55–1.05)	0.10	A	G			0.3526	1.46 (0.78–2.74)	0.24
G	G			0.2473	0.76 (0.53–1.09)	0.14	G	G			0.2595	0.83 (0.41–1.68)	0.61
IRF4rs1050975	IRF4rs1877175	IRF4rs7768807	IRF4rs12203592	Freq	OR(95%CI)a	P-value	IRF4rs1050975	IRF4rs1877175	IRF4rs7768807	IRF4rs12203592	Freq	OR(95%CI)b	P-value
A	G	T	C	0.4034	1.00	–	A	G	T	C	0.3536	1.00	–
A	G	C	C	0.1948	1.32 (0.90–1.95)	0.16	A	G	C	C	0.2236	0.73 (0.34–1.56)	0.41
A	G	T	T	0.1094	1.12 (0.64–1.93)	0.70	A	A	T	C	0.1240	0.28 (0.08–0.95)	0.042
A	A	T	C	0.1075	0.76 (0.42–1.40)	0.39	A	G	T	T	0.1214	0.95 (0.38–2.37)	0.92
A	A	C	C	0.0718	0.89 (0.48–1.65)	0.71	G	G	T	C	0.0726	0.04 (0.00–0.71)	0.029
G	G	T	C	0.0716	0.74 (0.36-1.52)	0.41	A	A	C	C	0.0456	0.04 (0.00–111.9)	0.42

^aEstimates calculated according to a dominant model of inheritance and adjusted for age, sex, country of origin, allo-SCT and underlying disease.

^bEstimates calculated according to a dominant model of inheritance and adjusted for age, sex, country of origin and underlying disease.