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. 2016 Aug 11;10:73. doi: 10.1186/s12918-016-0316-x

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Stochastic cellular responses of glioma cells to differentiation therapy simulated using the ANM model with different noise intensities. The noise intensity was set at 0.1, 1, 5 or 10 %. The upper panel a, b, c, d shows the probabilistic distribution of GFAP at 48 h during drug treatment (CT = 10 ng/ml) at different noise intensities. The lower panel e, f, g, h shows the stochastic temporal evolution of the differentiation potential of the glioma cell population at different noise intensities