Table 3.
Impact of rotavirus vaccination on hospitalisation and mortality due to diarrhoea in Latin America
| Study | Country | Vaccine | Outcome | Pre-vaccination | Post-vaccination | Difference (%) | ||
|---|---|---|---|---|---|---|---|---|
| Diarrhoea mortality | Year | Results | Year | Results | ||||
| do Carmo 2011 [7] | Brazil | RV1 | Annual death rates/100 000 children | 2002–2005 | <1 yr: 48 | 2007–2009 | <1 yr: 35 | −22 |
| 1 yr: 11 | 1 yr: 7 | −28 | ||||||
| 2–4 yr: 1 | 2–4 yr: 1 | −4 | ||||||
| All: 12 | All: 9 | −22 | ||||||
| Gurgel 2011 [45] | Brazil | RV1 | Number of hospitalisation | 2002–2005 | <1 yr: 986 | 2006–2009 | <1 yr: 449 | −54.5 |
| 1–4 yr: 237 | 1–4 yr: 159 | −32.9 | ||||||
| All: 1 223 | All: 608 | −50.3 | ||||||
| Lanzieri 2011 [46] | Brazil | RV1 | Annual death rates/100 000 children | 2004–2005 | <1 yr: 56.9 | 2008 | <1 yr: 34.9 | −39 |
| 1–4 yr: 4.5 | 1–4 yr: 3.0 | −33 | ||||||
| Richardson 2010 [49] | Mexico | RV1 | Annual death rates/100 000 children | 2003–2006 | <1 yr: 61.5 | 2008 | <1 yr: 25.5 | −41 |
| 1–2 yr: 21.1 | 1–2 yr: 6.1 | −29 | ||||||
| 2–5 yr: 2.9 | 2–5 yr: 0.2 | −7 | ||||||
| All: 18.1 | All: 6.3 | −35 | ||||||
| Gastañaduy 2013 [50] | Mexico | RV1 | Annual death rates/100 000 children | 2003–2006 | <1 yr: 59.1 | 2009–2011 | <1 yr: 28.4 | −52 |
| 1–2 yr: 19.6 | 1–2 yr: 7.9 | −60 | ||||||
| 2–5 yr: 2.8 | 2–5 yr: 2 | −26 | ||||||
| All: 17 | All: 8.5 | −50 | ||||||
| Bayard 2012 [53] | Panama | RV1 | Annual death rates/100 000 children | 2000–2005 | <1 yr: 73 | 2008 | <1 yr: 40 | −45 |
| 1–4 yr: 20.3 | 1–4 yr: 9 | −54 | ||||||
| All: 31.1 | All: 15.5 | −50 | ||||||
| Diarrhoea hospitalisation | ||||||||
| do Carmo 2011 [7] | Brazil | RV1 | Hospitalisation rates/100 000 children | 2002–2005 | <1 yr: 2 477 | 2007–2009 | <1 yr: 1 840 | −25 |
| 1 yr: 2 487 | 1 yr: 1 886 | −21 | ||||||
| 2–4 yr: 774 | 2–4 yr: 722 | −7 | ||||||
| All: 1 429 | All: 1 165 | −17 | ||||||
| Gurgel 2011 [45] | Brazil | RV1 | Number of hospitalisation | 2002–2005 | <1 yr: 194 348 | 2006–2009 | <1 yr: 125 151 | −35.6 |
| 1–4 yr: 301 479 | 1–4 yr: 264 376 | −12.3 | ||||||
| All: 495 827 | All: 389 527 | −21.4 | ||||||
| Masukawa 2014 [47] | Brazil | RV1 | Hospitalisation rates/100 000 children | 2000–2005 | <1 yr: 255.8 | 2007–2011 | <1 yr: 163.9 | −35.9 |
| 1 yr: 241.5 | 1 yr: 181.3 | −24.9 | ||||||
| 2 yr: 133.2 | 2 yr: 118.3 | −11.2 | ||||||
| 3 yr: 83.4 | 3 yr: 76.5 | −8.3 | ||||||
| Fernandes 2014 [48] | Brazil, São Paulo State | RV1 | Hospitalisation rates/100 000 children | 2000–2005 | <1 yr: 1 009.3 | 2008–2011 | <1 yr: 504.5 | −50 |
| 1 yr: 743.1 | 1 yr: 442.5 | −40 | ||||||
| 2–4 yr: 385.4 | 2–4 yr: 279.7 | −27 | ||||||
| All: 630.8 | All: 376.6 | −40 | ||||||
| Yen 2011 [55] | El Salvador | RV1 | Hospitalisation rates/100 000 children | 2005–2006 | <1 yr: 499 | 2008 | <1 yr: 79 | −84 |
| 1–2 yr: 447 | 1–2 yr: 63 | −86 | ||||||
| 2–3 yr: 123 | 2–3 yr: 43 | −65 | ||||||
| 3–4 yr: 30 | 3–4 yr: 18 | −41 | ||||||
| 4–5 yr: 26 | 4–5 yr: 8 | −68 | ||||||
| All: 225 | All: 42 | −81 | ||||||
| Yen 2011 [55] | El Salvador | RV1 | Hospitalisation rates/100 000 children | 2005–2006 | <1 yr: 499 | 2009 | <1 yr: 106 | −79 |
| 1–2 yr: 447 | 1–2 yr: 96 | −79 | ||||||
| 2–3 yr: 123 | 2–3 yr: 67 | −46 | ||||||
| 4–5 yr: 26 | 4–5 yr: 23 | −11 | ||||||
| All: 225 | All: 70 | −69 | ||||||
| Quintanar-Solares 2011 [52] | Mexico | RV1 | Number of hospitalisation | 2003–2006 | <1 yr: 5 133 | 2009 | <1 yr: 6 597 | −40 |
| 1–2 yr: 3 944 | 1–2 yr: 2 441 | −52 | ||||||
| 2–5 yr: 1 853 | 2–5 yr: 2 265 | −43 | ||||||
| Esparza-Aguilar 2014 [51] | Mexico | RV1 | Hospitalisation rates/10 000 children | 2003–2006 | <1 yr: 684 | 2008–2011 | <1 yr: 358 | −48 |
| 1–2 yr: 2 301 | 1–2 yr: 1 195 | −48 | ||||||
| 2–5 yr: 888 | 2–5 yr: 733 | −18 | ||||||
| All: 945 | All: 590 | −38 | ||||||
| Molto 2011 [54] | Panama | RV1 | Number of hospitalisation | 2000–2005 | <1 yr: 1 359 | 2008 | <1 yr: 941 | −31 |
| 1–4 yr: 2 698 | 1–4 yr: 1 614 | −40 | ||||||
| All: 4 057 | All: 2 555 | −37 | ||||||
| Bayard 2012 [53] | Panama | RV1 | Number of hospitalisation | 2000–2005 | <1 yr: 1 062 | 2008 | <1 yr: 762 | −28 |
| 1–4 yr: 1 942 | 1–4 yr: 1 347 | −31 | ||||||
| All: 3 004 | All: 2 109 | −30 | ||||||