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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Arthritis Rheumatol. 2016 Jul;68(7):1637–1647. doi: 10.1002/art.39631

Figure 3.

Figure 3

Synovial marker gene expression and association with COL-2 3/4C short levels. (A) Amongst the assessed set of 69 markers of monocytes, macrophages, lymphocytes and their function 13 were differentially expressed in at least one comparison of the three groups. ACL transection induced an upregulation of monocyte (CX3CR1, CCR1) and macrophage surface receptors (IL4R), M1 (SOCS3 and MARCO) and M2 (CHI3L1) macrophage markers, as well as proteases (MMP1, MMP2) and a protease inhibitor (TIMP1) when compared to uninjured controls, indicated by *. Corticosteroid administration resulted in significant downregulation of CX3CR1 and significant upregulation of MMP8 when compared to untreated ACL transection, indicated by #. Bars represent mean fold-changes relative to intact controls, error bars indicate standard errors of the means. (B) Amongst these genes, MARCO, SOCS3, CCR1, IL4R and MMP2 were significantly associated with the synovial fluid concentration of COL-2 3/4C short fragment levels. X-axis depicts the reads per kilobase of exon model per million mapped reads [RPKM], dotted lines depict 95% confidence intervals of regressed lines.