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. 2016 Aug 12;7:1149. doi: 10.3389/fmicb.2016.01149

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Copyright © 2016 Juillard, Tan, Li and Kaye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model of LANA tethering the KSHV genome to a chromosome. N-terminal LANA (N) binds to core histones H2A/H2B. C-terminal LANA (C) self-associates, binds to KSHV TR DNA in the KSHV genome, and binds to a putative protein (X) that associates with the chromosome.