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Lipopolysaccharide (LPS) structure and the core-lipid A biosynthetic pathway. (A) A graphic representation of the LPS structure of E. coli. LPS contains several conserved components: lipid A, inner core, outer core and O-antigen (Raetz and Whitfield, 2002). (B) Pathways for the biosynthesis of the LPS core lipid A (Raetz and Whitfield, 2002). The genes encode the catalytic enzymes for ADP-L-glycero-D-manno-heptose and core-lipid A biosynthesis are presented in rectangular boxes.
