Figure 5.
Case 5 was an oncocytic intraductal papillary mucinous neoplasm that had an invasive adenocarcinoma component identified on resection. (A) Smears reveal numerous 3-dimensional clusters of oncocytic cells with background necrotic debris (Diff-Quik stain). (B) There is marked nuclear pleomorphism and single-cell necrosis (Papanicolaou stain). (C) Prominent nucleoli and nuclear irregularity were striking in some areas (Papanicolaou stain). (D) A cell block revealed multiple, broad papillae with striking basophilic edema lined by oncocytic cells with occasional intranuclear inclusions (inset) and large, hyperchromatic nuclei (H&E stain).