Skip to main content
. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: J Pharm Sci. 2016 Jun 30;105(8):2459–2464. doi: 10.1016/j.xphs.2016.05.023

Figure 3. WBCT data and model fit.

Figure 3

WBCT vs time profiles after i.v. bolus doses of 50 U/kg free and PI-rcFVIII in HA dogs. Circles represent individual observed values and the lines represent the model fit. The dashed blue line represents a WBCT of 20 min-the threshold below which spontaneous bleeding is prevented in these dogs. Dotted blue lines represent the WBCT range in dogs with a normal clotting phenotype (8-12 min). Dotted black and red lines represent mean baseline WBCT values prior to free and PI-rcFVIII administration respectively. rcFVIII treatment corrected clotting phenotype to normal levels immediately post dose followed by return to baseline over time which was more gradual after PI-rcFVIII treatment. Return to WBCT values of 20min was prolonged after PI-rcFVIII treatment in one dog.