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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: J Pharm Sci. 2016 Jun 30;105(8):2459–2464. doi: 10.1016/j.xphs.2016.05.023

Table 3.

Pharmacokinetic model parameter estimates

Parameter Chromogenic assay aPTT
Free rcFVIII PI-rcFVIII Free rcFVIII PI-rcFVIII
CL (CV%) (mL/h × kg) 3.16(5.33) 2.44(5.39) 4.49(8.74) 2.97(8.37)
Vss (CV%) (mL/kg) 40.2(6.05) 40.6(11.1) 30.6(10.6)

CL = clearance, Vss= volume of distribution